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Junya Kobayashi Selected Research

Nijmegen Breakage Syndrome

7/2017NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein.
3/2009[DNA double strand break and Nijmegen breakage syndrome].
3/2009Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway.
1/2004Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex.
1/2004Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex.
10/2002NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.

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Junya Kobayashi Research Topics

Disease

8Genomic Instability
01/2020 - 12/2002
8Ataxia Telangiectasia (Louis Bar Syndrome)
05/2019 - 05/2006
6Neoplasms (Cancer)
05/2019 - 07/2014
6Nijmegen Breakage Syndrome
07/2017 - 10/2002
4Stomach Neoplasms (Stomach Cancer)
06/2018 - 01/2011
3Carcinogenesis
05/2019 - 10/2008
2Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome)
03/2021 - 09/2012
2Ischemic Stroke
01/2019 - 09/2017
2Hypersensitivity (Allergy)
07/2014 - 11/2007
1Myositis (Idiopathic Inflammatory Myopathies)
09/2021
1Renal Cell Carcinoma (Grawitz Tumor)
09/2021
1Myasthenia Gravis
09/2021
1Lymphatic Metastasis
09/2021
1Deglutition Disorders (Dysphagia)
09/2021
1Diplopia (Double Vision)
09/2021
1Inflammation (Inflammations)
09/2021
1Melanosis (Freckles)
06/2018
1Infections
01/2018
1Atrial Fibrillation
09/2017
1Stroke (Strokes)
09/2017
1Chromosomal Instability (Chromosome Stability)
07/2017
1Inborn Genetic Diseases (Disease, Hereditary)
07/2017
1Hyperammonemia
01/2017
1Urinary Tract Infections (Urinary Tract Infection)
01/2017
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
12/2015
1Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2015
1Cerebellar Ataxia (Dysmetria)
04/2015
1Breast Neoplasms (Breast Cancer)
01/2015
1Werner Syndrome (Werner's Syndrome)
11/2014
1autosomal recessive 1 Spinocerebellar ataxia
05/2013
1Ataxia (Dyssynergia)
05/2013
1Bites and Stings (Sting)
02/2013
1Ovarian Neoplasms (Ovarian Cancer)
09/2012
1Dementia (Dementias)
02/2012
1Ascites
12/2011
1Myocardial Ischemia (Ischemic Heart Diseases)
10/2010
1X-Linked Mental Retardation (Mental Retardation, X Linked)
04/2010
1Multiple Organ Failure (MODS)
10/2008
1Shock
10/2008
1Tooth Loss
05/2003

Drug/Important Bio-Agent (IBA)

20DNA (Deoxyribonucleic Acid)IBA
03/2021 - 10/2002
6Proteins (Proteins, Gene)FDA Link
01/2018 - 12/2002
4lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
03/2021 - 03/2007
31,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
01/2018 - 01/2015
3Phosphotransferases (Kinase)IBA
09/2013 - 05/2006
2Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2015 - 11/2007
2Paclitaxel (Taxol)FDA LinkGeneric
12/2011 - 01/2011
2doxifluridineIBA
12/2011 - 01/2011
1ConnectinIBA
09/2021
1anti-titin autoantibodyIBA
09/2021
1Creatine Kinase (Creatine Phosphokinase)IBA
09/2021
1Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA
09/2021
1AntibodiesIBA
09/2021
1Immune Checkpoint InhibitorsIBA
09/2021
1Biomarkers (Surrogate Marker)IBA
09/2021
1NivolumabIBA
09/2021
1IpilimumabIBA
09/2021
1Acetylcysteine (Siran)FDA LinkGeneric
01/2020
1Nuclear Proteins (Protein, Nuclear)IBA
05/2019
1NucleolinIBA
05/2019
1Ribosomal DNA (rDNA)IBA
05/2019
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2018
1Bromodeoxyuridine (BrdU)IBA
11/2018
1vpr Gene ProductsIBA
01/2018
1Glutathione (Reduced Glutathione)IBA
03/2017
1AntioxidantsIBA
03/2017
1UreaseIBA
01/2017
1Doxorubicin (Adriamycin)FDA LinkGeneric
12/2015
1Bleomycin (Blenoxane)FDA LinkGeneric
12/2015
1WT1 ProteinsIBA
12/2015
1Protein Isoforms (Isoforms)IBA
12/2015
1Reactive Oxygen Species (Oxygen Radicals)IBA
04/2015
1CamptothecinIBA
07/2014
1Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA
07/2014
1Interferon Type IIBA
02/2013
1C-Reactive ProteinIBA
10/2010
1Urea (Carbamide)FDA LinkGeneric
10/2010
1AlbuminsIBA
10/2010
1NitrogenIBA
10/2010
1DNA HelicasesIBA
06/2010
1Nonsense Codon (Nonsense Mutation)IBA
04/2010
1Protein Kinases (Protein Kinase)IBA
01/2009
1DNA-Activated Protein KinaseIBA
01/2009
1Phosphatidylinositols (Phosphatidylinositol)IBA
01/2009
1Dacarbazine (DIC)FDA LinkGeneric
10/2008
1Estrogens (Estrogen)FDA Link
05/2003
1Calcitriol Receptors (Calcitriol Receptor)IBA
05/2003
1Estrogen ReceptorsIBA
05/2003
1Histones (Histone)IBA
10/2002

Therapy/Procedure

2Drug Therapy (Chemotherapy)
05/2019 - 12/2011
2Radiotherapy
05/2019 - 07/2014
2Therapeutics
01/2019 - 09/2017
1Aftercare (After-Treatment)
09/2021
1Gastrectomy
06/2018
1Heterologous Transplantation (Xenotransplantation)
09/2012
1Tissue Transplantation
09/2012
1Stem Cell Transplantation
09/2012
1Gastrostomy
02/2012
1Combination Drug Therapy (Combination Chemotherapy)
01/2011